Mar
New Genetic Risk Factors for Sudden Cardiac Death

One known cause of SCD is Hypertrophic cardiomyopathy (HCM), a disease in which the heart muscle becomes abnormally thick, making it harder for the heart to pump blood. HCM often goes undetected and is the most common cause of sudden death in athletes. SCD can also occur in people who are born with coronary arteries that are abnormally connected to the heart. During exercise, these arteries may become compressed and unable provide proper blood flow to the heart.
However, with the lack of telltale symptoms and limited availability of diagnostic tests to detect SCD, predicting who is at risk is largely dependent upon genetics. An international team of researchers including members from the Johns Hopkins University School of Medicine, the Technical University in Munich as well as others have now identified 10 common variants of genes that alter QT interval, or the timing of the contraction of the heart, that may help to pinpoint predisposition for sudden cardiac death. The study has recently been published in Nature Genetics.
Among the other genes identified, several had been suspected. However, according to Dan Arking, Ph.D., an assistant professor in the McKusick-Nathans Institute of Genetic Medicine, “almost half were surprising new genes that no one would have guessed as being involved in cardiac biology.” Arking also stated, “It really does open up a new world of investigation because these are genes that would have never come up if we had only focused on a list of known candidate genes.”
As a kid, I had a bunch of little round magnets that were supposed to be glued onto the back of homemade refrigerator magnets. Instead I used to stack them up on the kitchen table and turn them around and around attracting and repelling the little discs for the sheer wonder of the power they held. Little did I know magnets have been widely used as an alternative method of treating pain from headaches and motion sickness to joint pain.
Health care in the United States is preparing to be put to the test. At a crucial time in the economic history of the country, advances made toward providing health care to more and more people may not be enough to counter the vast numbers of citizens losing health care benefits in the current recession. While it may be months or years before the truth is revealed in numbers and statistics, there is no doubt that the health care system is now facing one of its greatest challenges in decades.