Serious obesity requires drastic actions, usually surgical in nature. Lap band procedures and gastric bypass have a good success rate but do come with risks associated with surgery.

Finding a non-invasive way to lose weight has been elusive for researchers, until now. Currently in the initial testing stages on rodents, the “magic stick,” a weekly injection to help decrease appetites and increase metabolism, may be the next generation of weight loss remedies.

The injection consists of two natural hormones, glucagon and glucagon like peptide  which are similar in structure but different in their chemical make-up and biological function. Initial results show that subsequent weight loss could be comparable to that achieved through gastric bypass.

Richard DiMarchi, lead author of the rodent study and chairman of the Chemistry Department at Indiana University said, “I’m excited. It is rodent work that’s representative of human obesity.” He added, “What we’re doing is using the proven ability of two hormones to stop appetite and use more calories.”

According to Professor DiMarchi, the mice and rats used for his study were overfed so their body weights were around two times what their normal body weight should be. During the study, the rodents were injected with a single injection containing the two natural hormones and after only a single shot lost 25 percent of their body weight and then after a month of weekly shots the rodents were back to their normal body weight.

While DiMarchi says he doesn’t expect humans to benefit as well as the rodents and it would probably not be healthy if they did. The shot has the potential to reduce weight comparable to the results seen from gastric bypass surgery.

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